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Pharmacologic screening identifies metabolic vulnerabilities of CD8(+) T cells

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Takotsubo syndrome associated with structural brain alterations of the limbic system

A major way glutathione protects cells is through glutathione-dependent enzymes , especially glutathione peroxidases (GPx) , which use GSH to reduce peroxides (including hydrogen peroxide) into less reactive compounds

Clinical trials have established the proof-of-concept for intrathecal ASO therapy, exemplified by tofersen for SOD1-ALS, which achieved accelerated approval based on biomarker reduction despite not meeting the primary clinical endpoint in its phase 3 VALOR trial (8, 43, 44)

Plant Cell Environ 43:11751191 Acknowledgements The author thanks the French Agence Nationale de la Recherche HIPATH project (ANR-17-CE20-0025) and the Institut Universitaire de France (IUF) for financial support